Diane Henry was a houseguest in Big Brother 5. Throughout the season, she was known for her showmance with Drew Daniel, as well as being a member of the powerful Pinky Swear Alliance. Once the alliance crumbled, she aligned with Drew and his ally Cowboy. She was evicted by Drew in the final 3, causing her to be the seventh and final member of the jury in Big Brother 5.
She would later return in Big Brother All Stars. In this season, she aligned with Nakomis once again and formed a side alliance with her former rival Jase, which was known as the Mr and Mrs Smith alliance. After her alliance members were evicted back-to-back, Diane was nominated as the replacement nominee by Janelle when Mike used the veto to take himself off the block. On eviction night, she was evicted by a 7-1 vote, placing 11th.