Pierzina returned to the house in Big Brother All-Stars, being reunited with three of her Sovereign Six allies. In this season, Janelle set the record for most individual competitions won in a single season. Once again, she placed third. She also developed a flirtmance with Will Kirby where the two formed a connection with one another but ultimately stayed friends due to both being in relationships outside the house. At the finale of the season, Janelle was awarded $25,000 as the winner of the Fan Favorite Award.
Janelle returned along with three former houseguests for Big Brother 14, as part of the coaches twist. During Week 3, Janelle re-entered the game for her third time. Janelle was the fourth houseguest evicted, placing twelfth out of sixteen, after Mike "Boogie" Malin convinced Danielle Murphree to backdoor Janelle, allowing her no chance to save herself.
Because of her competition prowess, she is regarded as the greatest female houseguest and one of the greatest players in the history of the show.
Pierzina was born in Grand Rapids, Minnesota, she graduated from Grand Rapids High School in 1998, and graduated with a degree in communications from the University of Minnesota Duluth. Prior to Big Brother, Pierzina was an actress, a model, and a waiter.
On June 11, 2009 Janelle announced her engagement to Jess DeSanto. The two married in 2010. Janelle gave birth to a baby girl on December 14th, 2011 and named her Violet Anne DeSanto. On August 10th, 2013, Janelle gave birth to a baby boy named Lincoln William DeSanto, who shares the same birthday with one of Janelle's former alliance members of the Sovereign Six, Kaysar Ridha. Her third child, Stella Rose DeSanto, was born on September 26th, 2014.
She, Aaryn, Caleb, and Vanessa are the the only ones to not win the game.
Janelle is one of two houseguests (along with Mike "Boogie" Malin) to play for a third time in three different seasons. Mike has outlasted her in the two seasons they competed in together, but only two spots higher each time.
Despite this, Janelle still has a higher placing average than Mike.
Janelle holds the record for the most individual competitions won in a single season with 9, by winning 4 Head of Household's and 5 Power of Veto's. Janelle also holds the record for most individual competitions won in multiple seasons with 6 HOH's (tied with Rachel Reilly), 7 POV's, and 2 Coaches Competitions – making a total of 15 competitions.
Janelle was the only houseguest to win challenges on Team Janelle in Big Brother 14.
Janelle is the only female member of the Sovereign Six alliance to return for another season.
Janelle has used the Power of Veto more than any other HouseGuest (6 out of 7 wins)